Accelerated R&D in Europe (CARE) has been launched by a European consortium forming a united front dedicated to COVID-19 R&D for better and more accessible treatments for COVID-19 throughout the continent. It is the first endeavor of its kind and seeks to research, create, and develop new drugs and antibodies as effective therapies for COVID-19.
CARE comprises 37 public-private partners, including universities, research centers, small and medium enterprises, academic professionals, scientists, in association with the European Federation of Pharmaceutical Industries and Associations (EFPIA), and the Innovative Medicines Initiative (IMI). Their combined capabilities aim to bolster COVID-19 R&D efforts for a more stable future.
“Beyond the scientific excellence of the different teams involved in this very ambitious project, CARE is bringing together 37 partners in an alliance pooling their expertise and know-how around an ambitious five-year work plan to develop therapeutics against the current COVID-19 pandemic”, said Executive Director of the VRI-Inserm and CARE Coordinator, Professor Yves Levy. “We are very grateful for the financial support provided by the Innovative Medicine Initiative that will enable us to implement this plan.”
By means of a computer modeling and simulation technique called ‘in silico’ screening and analysis, researchers will search through and examine existing treatments of other ailments related to covid-19, and viruses like it, to be repurposed for COVID-19.
After analyzing and profiling possible candidates, top picks will undergo the first rounds of testing. From there, the most promising options will move on to the next stages involving human participants.
With the combined efforts and resources of every member and the drive and spirit to work fast and collaborate, CARE might be able to hit turbo on COVID-19 R&D, and hopefully achieve life-saving results.
“COVID-19 is a once in a lifetime scientific challenge for our generation,” said Kumar Saikatendu, Director of Global Research Externalization, Takeda. “CARE aims to create effective therapies with a positive safety profile for current and future coronaviral outbreaks. We hope to move fast and have a meaningful impact in a timely manner.”
Impacts of the pandemic on SMEs: First in, first out
The pandemic sent shockwaves across the world with many SMEs bearing the brunt of the crisis due to the reduction in global demand for goods and services.
The worst effect of the pandemic on SMEs were the mass layoffs seen throughout all industries, although disproportionately. Disposable income that could have circulated in the economy became scarce, leaving many SMEs susceptible to permanent closure as people spend their money with greater caution. This was only a few weeks into the crisis, and prior to any government aid.
Business owners had very different predictions about the duration of the pandemic, leading them to make varied decisions on whether or not to keep their employees, cut their losses, or whether to save up or spend their stimulus checks. Many business owners were paying from their own pocket to stay afloat, and could not last more than a few weeks or few months, with layoffs.
A survey of more than 5,800 small businesses between March 28 and April 4, 2020 was conducted to determine how adaptable businesses were to the sudden change of the market and social landscape, and the impacts of the pandemic on SMEs.
According to the survey, 92% of SMEs changed at least one thing in their business model to adapt to COVID-19, most using some form of digital technology to bypass, adapt, or improve many traditional – potentially risky – ways of doing business.
Noting that some companies selected more than one option, the changes were listed as follows:
- 58% of businesses said that they had adopted a new online delivery channel
- 40% created new virtual services
- 36% listed the use of a new offline delivery channel, such as Uber Eats.
- 31% had released a new product.
- 19% new customers
Consequently, the survey also listed the 5 most commonly mentioned challenges that these businesses have experienced:
- 22% lack of employee skills
- 16% lack of adequate funds
- 14% setting up new online delivery channels
- 9% developing new products.
- 8% faced challenges adapting to the new health and safety standards
Top 3 digital health technologies post- pandemic
It’s certain that the current pandemic will eventually come to an end. However, some of the digital health technologies we’ve adopted along the way have proven to be indispensable, and some technologies may not be so prominent after the crisis.
Here are top 3 digital health technologies that are likely to stick around post- pandemic.
1. Disinfectant robots
Ultraviolet (UV) lights, more specifically UV-C is a well-established digital disinfecting method that is commonly used in the healthcare world. It works by altering the virus’ genetic material, that way UV lights make sure that virus doesn’t replicate. However, if exposed to human skin, it can lead to sunburns, irritations, and in the worst case, skin cancer.
All that aside, the benefits of UV-C in effectively disinfecting hospitals is seriously attracting robotics engineers and healthcare workers alike. Companies such as YouiBot are reimagining and redesigning their current robots into UV disinfectant ones. Danish company UVD Robots has shipped hundreds of their existing disinfectant robots around the world during the pandemic.
In addition to saving valuable time and decreasing the spread of COVID-19 in hospitals, these robots will also prevent hospitals from getting infections.
2. AI for predicting future pandemics
In an ideal tech world, AI can predict a viral outbreak weeks, if not months in advance. Unfortunately, we don’t live in an ideal tech world, but the good news is that we can work towards forecasting such a system with the help of current technologies.
AI company BlueDot has issued early first warnings, after scrutinizing massive data sets from news, airlines, and animal disease outbreaks. Their algorithim managed to detect a certain trend which Epidemiologists later analyzed further to confirm an outbreak.
But BlueDot is the exception and not the rule, so we must reverse the situation in order to better handle the next public health crisis. Given the massive predictive power that AI brings to the healthcare sector, the proper authorities should utilize its full potential and help in making it more commonplace in hospital settings.
3. Remote care via smartphones
It’s a sad reality that the pandemic kick-started telemedicine for mainstream adoption. Before the crisis, only 1 in 10 US patients used telemedicine services, the number has now increased up to 158% in the same country.
With lockdowns enforced globally, people are utilizing the power of their smartphones for their mental and physical wellbeing. These new digital health technologies greatly reduce the risk of cross infection all while offering patients quality care from the comfort of their own homes
These solutions greatly reduce the risk of cross-infection while offering patients quality care from the comfort of their homes. What’s more, they prove that face-to-face doctor-patient visits are unnecessary. A Global Markets Insights report from April this year, projects that the telemedicine market value will reach $175.5 billion by 2026, indicating the need for remote care in the coming years.
The glaring problem with COVID-19 vaccine deployment
As most of us already know, creating a vaccine is only half the challenge of beating the pandemic. Getting 7 billion people vaccinated is a colossal undertaking, the scale of which has never been seen in history. How will the world manage and sustain COVID-19 vaccine deployment, and ensure equitable access to everyone?
It is not an easy task, and many people in positions of responsibility may have to make some difficult decisions. In short, we will not have enough vaccines for everyone by the end of this year, even if a particular vaccine candidate is deemed adequate.
In a document by the CDC published as a rough skeletal guideline, four categories of people were prioritized with newly produced or procured vaccine doses. This is to strategically use the scarce resources available to minimize the loss of life and maximize equity.
The document classified four categories of people that would receive the vaccine at different times according to a number of factors:
– High risk healthcare workers. First responders
– High risk older adults in congregate or crowded settings
Workers in critical industries and those living in an environment of high risk such as prison.
Young adults and children, and workers of essential industries that were not included in phase 2.
In an Audio Interview “Guidelines for Covid-19 Vaccine Deployment”, Eric J. Rubin, M.D., Ph.D. concurred. “We do this in medicine all the time”, he said “in that we plan to treat everybody but those who get sicker are the ones who need the treatment first, while we are scaling up or making any assessment of deploying a treatment”.
This task becomes more difficult in areas were the data on who needs what is scarce. Numerous collectives and institutions however are finding ways to guide their communities using localized data tracking, remote monitoring and some forms of contact tracing. They will be able to identify where and how many people require vaccination, how many vaccines are available for the taking, when more is coming, etc.
Having a clear picture is essential for any major endeavor to succeed, and a type of “communal immunity” can be achieved, to break the back of community transmission” as Rubin put it.
The issue of Covid-19 Vaccine Deployment isn’t when the vaccine is coming, but “who gets it first”. The answer given by the CDC seems to be a good one, from the perspective of the scientist, who have accepted the reality that vaccine equity is no easy task, and hard decisions must be made.
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