Covid-19 vaccine-making veteran Moderna seems unfazed by the emergence of the Omicron variant, saying that they can begin work on developing a booster short within a couple of weeks, according to Chief Executive Stephane Bancel.
“It only needs minor adjustments for Omicron, I don’t expect any problems,” said Bancel in an interview with the Swiss newspaper TagesAnzeiger.
Though hoping to begin clinical trials in early 2022, for the time being, they will be relying on the booster dose of their mRNA-1273 vaccine to counter the fast-spreading coronavirus variant.
The company is now awaiting vital information on the new variant to begin vaccine development, which could take up to one or two weeks.
Bancel says that it will take another few months to produce 500 million doses after all the regulatory requirements have been met, citing that their capabilities and experience as a company today have increased compared to one year ago.
In 2021, Moderna managed to create around 700 million to 800 million vaccine doses. In 2022, they expect to escalate production capacity from 100 million doses per month to 150 million per month.
Deals were also made with Swiss-based drug manufacturer Lonza to boost production further and plan to fire up their factory lines in the first quarter of 2022.
The company is currently discussing a future ‘vaccine subscription’ service with Switzerland that works to ensure a steady supply. This move helps improve ties with the country, which Moderna is keen to proceed with after signing parliamentary agreements with Canada and Australia.
“We have a number of new vaccines in development, for example against influenza or against the RS virus, which causes a respiratory disease that is fatal in the elderly and young children,” Bancel added.
“We can combine these three mRNA vaccines into one dose and propose to governments to secure supplies for a certain amount for several years and then invest in a production facility in that country,” he added.
With this, the company can designate certain countries as having priority should another pandemic occur in the future.
Vista Equity invests $300 million in telehealth software firm TigerConnect- sources
Healthcare communications software provider TigerConnect has raised $300 million in growth investment from private equity firm Vista Equity Partners, sources familiar with the matter told Reuters on Monday.
The valuation of TigerConnect wasn’t known. It last raised $45 million at a valuation of $370 million in September 2020, according to PitchBook data, counting HealthQuest Capital and New Leaf Ventures as its backers. Some of the early investors have exited through Vista’s investment, one of the sources said.
Santa Monica, California-based TigerConnect delivers cloud-based clinical communication and collaboration solutions, including telehealth, to over 7,000 healthcare organizations and 700,000 caregivers.
In an interview, Brad Brooks, TigerConnect’s co-founder and chief executive confirmed the partnership with Vista, but declined to comment on the amount or valuation.
He said the company plans to use the proceeds to invest in its product to meet the growing need for clinical collaborations, as well as looking for acquisition opportunities.
The number of users on TigerConnect’s platform more than doubled during the past year as hospitals try to improve efficiency and the experience for patients during the pandemic, Brooks added.
“There had really been a dramatic lack of efforts around clinical workflow communication. We’re almost like a Slack for healthcare, putting in a common communication network so that everyone can reach everyone,” said Brooks.
The company, founded in 2010, sells subscription-based software solutions, including collaboration, communication, scheduling and patient engagement. It also plans to utilize AI and machine learning technology to provide smart solutions based on the platform data.
Vista has over $86 billion in assets under management and specializes in investing in enterprise software, data and technology companies. Last week, it invested an undisclosed amount in BlueConic, a Boston-based customer data platform.
AstraZeneca booster shot is effective against Omicron variant
A study from an Oxford University lab published on Thursday revealed that a three-dose course of AstraZeneca booster shot is efficient in controlling the fast spread of the Omicron variant.
The Pharmaceutical company said in its statement that the results – while they have yet to be released in a peer-reviewed medical journal – are relatively identical to those of its rivals, including Pfizer-BioNTech and Moderna. They also uncovered that their booster vaccines effectively fight the latest Coronavirus variant.
After receiving the third dose of AstraZeneca, the study highlighted that the shot had a neutralizing effect against the virus, which had an almost identical result to the two shots against its previous variant, Delta.
“As we better understand Omicron, we believe we will find T-cell response provides durable protection against severe disease and hospitalizations,” the head of AstraZeneca’s biopharmaceutical R&D, Mene Pangalos, said when referring to a significant element of the immune system that fights infection.
After taking the Vaxzervria – the third booster shot – antibody levels marked a much higher rate than antibodies in patients who had already caught the virus and naturally regained health, the Anglo-Swedish drugmaker said.
On Tuesday, the pharmaceutical firm announced that it is already working with its partner, Oxford University, to develop a vaccine exclusively directed towards fighting the Omicron variant, mirroring other MedTech companies’ attempts.
The university’s study incorporated 41 samples from individuals who had already taken the first two shots of AstraZeneca and others who took the booster one. The lab examined and analyzed blood samples from people infected with the virus and others vaccinated with the two dozes, the third booster shot, and finally, those who had already caught one of the coronavirus variants.
It is worth mentioning that AstraZeneca stated that while the Oxford University lab results support its booster shot, the study was completely independent of researchers who had previously joint efforts with the London-based firm on the vaccine.
The world is looking to halt back from the detrimental effect the pandemic is spreading, with governments and scientists seeking to heighten fortifications in their health sectors against the Omicron.
Even since its emergence on the scene, the latest COVID-19 variant proved to be one of the most dominant variants to date. Governments are worried it might become globally spread after the holidays if they fail to curb the infections rate.
Earlier this month, the UK endorsed third shots after discovering that boosters have a vital role in restoring protection against other diseases triggered by the Omicron.
EU approves 5th COVID-19 vaccine for bloc, one by Novavax
The European Union’s drugs regulator gave the green light Monday to a fifth COVID-19 vaccine for use in the 27-nation bloc, granting conditional marketing authorization to the two-dose vaccine made by U.S. biotech company Novavax.
The European Medicines Agency decision to recommend granting conditional marketing authorization for the vaccine for people aged 18 and over, which must be confirmed by the EU’s executive commission, comes as many European nations are battling surges in infections and amid concerns about the spread of the new omicron variant.
Novavax says it currently is testing how its shots will hold up against the omicron variant, and like other manufacturers has begun formulating an updated version to better match that variant in case in case it’s eventually needed.
The Novavax shot joins those from Pfizer-BioNTech, Moderna, Johnson & Johnson and AstraZeneca in the EU’s vaccine armory. The EU has ordered up to 100 million doses of the Novavax vaccine with an option for 100 million more.
Last week, the World Health Organization gave emergency approval to the Novavax vaccine, paving the way for its inclusion in the U.N.-backed program to get such vaccines to poorer countries around the world.
The EMA said that it’s human medicines committee concluded by consensus “that the data on the vaccine were robust and met the EU criteria for efficacy, safety and quality.”
COVID-19 vaccines train the body to recognize the coronavirus by spotting the spike protein that coats it, but the Novavax option is made very differently than the most widely used shots.
It is a protein vaccine, made with an older technology that’s been used for years to produce other kinds of vaccines. The Maryland-based Novavax uses genetic engineering to grow harmless copies of the coronavirus spike protein in insect cells. Scientists extract and purify the protein and then mix in an immune-boosting chemical.
Novavax President and CEO Stanley C. Erck said if the European Commission confirms the EMA decision the company would “deliver the first protein-based vaccine to the E.U. during a critical time when we believe having choice among vaccines will lead to increased immunization.”
Last summer, Novavax reported a study of 30,000 people in the U.S. and Mexico found the vaccine was safe and 90% effective against symptomatic infection from earlier variants, similar to findings from a trial of 15,000 people in Britain. A follow-up study found a booster dose six months after the last shot could rev up virus-fighting antibodies enough to tackle the extra-contagious delta variant, which at the time was the biggest threat.
It was not immediately clear how much supply Novavax will be able to ship, and when. Its vaccine was long anticipated to help increase global vaccine supplies, as the shots require only refrigerated storage. But Novavax was delayed for months because of problems lining up large-scale manufacturing.
In a staetment, Novavax said the Serum Institute of India manufacturer will supply the initial doses for the EU and later doses will come from other manufacturing sites in its global supply chain.
Dr. Gregory Glenn, Novavax’s research and development chief, recently told The Associated Press the problem wasn’t producing the spike protein itself, which is straightforward, but capacity to make and bottle large quantities. Glenn said the company now has enough manufacturing capability. It partnered with the huge Serum Institute of India, and two companies recently received emergency authorization of the shots in Indonesia and the Philippines. In addition, Novavax has lined up production facilities in the Czech Republic, South Korea and elsewhere.
Novavax has been given emergency use authorization in Indonesia and the Philippines, has applications pending with the World Health Organization and Britain, and plans to file with the U.S. Food and Drug Administration by year’s end.
THE HAGUE, Netherlands (AP)
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